DENVER -- Even when the San Francisco Giants pick up a rare win at Coors Field, they still lose. Barry Bonds Jersey . In this case, two pitchers -- starter Matt Cain and reliever Santiago Casilla, who both strained their right hamstrings and will undergo MRIs to determine the severity. Hunter Pence hit one of San Franciscos three solo homers and reliever Yusmeiro Petit threw three sharp innings after Cain left as the Giants beat the Colorado Rockies 5-1 on Wednesday night. "The win was great," Pence said, "but its a huge blow to lose Cain and Casilla." Pablo Sandoval and Brandon Crawford also connected for the NL West-leading Giants, who won at this hitter friendly venue for just the fifth time in 15 games dating back to last season. Cain had good command and was cruising along, not allowing a hit through three innings. Then, on his last pitch of the third, he felt a twinge in his hamstring. Casilla was hurt in the ninth inning when he tried to beat out an infield hit, falling over the bag and rolling several times on the field. He was helped to the dugout by the trainers and was replaced on the mound by Jeremy Affeldt, who finished the game. To think, just moments before in the dugout, Giants manager Bruce Bochy told Casilla to not even bother swinging -- just take it easy at the plate. "I was shocked he was running like that," Bochy said. "Guess he thought he had a hit. I dont know what got into him. Never seen him run like that." Petit (3-1) pitched effectively in Cains place as he and four other relievers limited the best offensive team in the majors to just five hits. Jhoulys Chacin (0-3) worked 5 2-3 innings and allowed three runs, including a homer to Pence in the fourth and another to Sandoval two innings later. "Two bad pitches, two homers, two runs," Chacin said. "I pitched good. We lost and thats all I care about." Crawford added a solo shot off Matt Belisle in the seventh as the Giants took the middle contest to even the three-game series. The Rockies have yet to lose a series at home this year. Trailing 5-0 in the eighth, the Rockies loaded the bases with no outs. Michael Cuddyer sent a grounder up the middle that Crawford tracked down and scooped over to second base with his glove to start a double play. Troy Tulowitzki then flew out limit the damage to only a run. Cain was settling into a rhythm when Rockies second baseman D.J. LeMahieu sent a sharp comebacker at the right-hander in the third. While the ball glanced off Cains glove, the Giants came out to check on him. Cain said after the game that had nothing to do with his hamstring injury. Earlier this season, Cain missed 13 games after he cut his right index finger while making a ham-and-cheese sandwich in the Giants clubhouse. The cut didnt require stitches. Optimistic this injury will heal fast? "Well see how tomorrow it feels," Cain said. "Still got some adrenaline going. But its calming down." Carlos Gonzalez also was banged up as he left the game as part of a double-switch in the eighth because of inflammation in his left index finger. He said he had an X-ray during the game and its not broken. "One of those things I have to deal with and get treatment every day," the slugger said. Tulowitzkis torrid hitting at home this season (.521 with eight homers) caught the attention of Giants broadcaster and former major league pitcher Mike Krukow. "Youre always skeptical -- its just the way you are as a player," Krukow said before the game. "Hes hitting as if hes getting signs. Im not accusing anybody of anything." Still, Rockies manager Walt Weiss had some fun with the assertion his shortstop is somehow stealing signs. "We have a light bulb on the scoreboard we flash. Keep an eye on Dinger (the teams mascot), hes involved," Weiss said. "We switch out the balls. Got the umpires in on it. "I love it when other teams talk about that," Weiss said. "I think its great. I think it feeds the beast." NOTES: Bochy said Buster Posey (nerve irritation in lower back) is "doing a lot better" and the catcher could be in the lineup Thursday. ... RHP Tim Hudson (4-2) will take the mound in the series finale on Thursday. The Rockies will throw LHP Jorge De La Rosa (5-3). Willie Stargell Jersey . PAUL, Minn – The clock lingered for what seemed like an interminable two minutes and 51 seconds before Mark Fraser finally escaped to the bench during a wildly one-sided first period of an eventual loss to Boston. Melky Cabrera Jersey . Radulov scored the lone goal in the shootout, and the Predators edged the Minnesota Wild 2-1 on Tuesday night to reach 100 points for the second time in three seasons and fourth in seven. http://www.pittsburghpiratesprostore.us/Francisco-Liriano-pirates-jersey/ . Chelsea ripped apart Hull inside 25 minutes at Stamford Bridge, with the early goals from Oscar and Frank Lampard securing a 2-0 victory. While Lampard had earlier missed a penalty, Roberto Soldado had no such trouble from the spot for Tottenham, scoring on his debut to clinch a 1-0 victory over Crystal Palace.Mexico City, Mexico (SportsNetwork.com) -Reigning Apertura champions America opened their Clausura season with a 3-2 win over Leon on Saturday at the Estadio Azteca. America claimed a 3-1 aggregate win over Tigres in the Apertura final back in December to claim its 12th Mexican league title, and the club hoped to get the winter campaign on the right foot. It didnt take long for the defending champions to get off the mark as Mexico international Oribe Peralta found the back of the net after just three minutes and added a second tally four minutes later. Leon battled back to pull level at 2-2 when Moises Velasco netted an own goal and Mauro Boselli scored after 39 minutes, leaving all to play for in the second half. The winning tally came with 25 minutes left as Carlos Darwin Quintero fired past Leon goalkeeper William Yarbroough to secure all three points for America. Roberto Clemente Pirates Jersey. Also on the opening weekend of the Clausura, Matias Alustiza scored a pair of stunning goals to lead Puebla to a 2-1 win over Tijuana, while Edy Brambilas 79th-minute strike handed Atlas a 1-0 win over Tigres. Aviles Hurtado struck four minutes from time to give Jaguares a 2-1 result over Guadalajara, while Joao Rojas eighth-minute goal held up to hand Cruz Azul a 1-0 win over Pachuca. On Sunday, Victor Ismael Sosa and Edgar Pacheco traded goals as Pumas and Queretaro played to a 1-1 draw, while Fidel Martinez scored in the 67th minute to give Leones Negros a 1-0 victory over Monterrey. Fridays action, Leiton Jimenez Romero score a pair of second-half goals as Verzcruz claimed a 2-1 win over Santos, while Morelia and Toluca played to a scoreless draw. ' ' '